A method for the quantitative analysis of delta-9-tetrahydrocannabinol (THC, the main active ingredient of cannabis) in whole blood using solid phase extraction and LC/MS/MS has been developed. A bottom-up approach with method validation data was used to evaluate and estimate the measurement uncertainty (MU) of the analytical method. The sources of uncertainty were identified using a cause and effect diagram. The contribution of each uncertainty component was estimated and were combined to derive the overall uncertainty of the analytical method. The combined uncertainty was estimated to be 0.131?μg/L ( less then 7%). At a 99.7% confidence level, the expanded uncertainty was 0.393?μg/L for a THC concentration of 2?μg/L in a whole blood sample. The calculations not only enable the laboratory to quantify the uncertainty associated with a quantitative result, but can also be used to identify the sources of uncertainty and determine if the analytical method can be improved. An open access Measurement Uncertainty Calculator (MUCalc) software has been developed using the method described in this paper.Penetrating craniofacial wounds due to foreign bodies, specifically sharp white blades, represent an eventual life threatening condition and a rare case of emergency facial surgery requiring a complex medical care. We report an original case of a penetrating craniofacial wound by a knife with a review of the literature concerning the tendencies, the complications and the specific medical care needed for these particular cranio-facial lesions.
A 35 year old man admitted to our ENT emergency room with a penetrating craniofacial wound caused by a knife stuck in the cranio-orbital-nasal junction. A craniofacial profile x-ray showed the presence of the metallic foreign body, a knife, penetrating deeply to the base of the skull. Computed tomography showed that the transcranial metallic foreign body arrived in the right sellar region after passing through the nasal cavity and the right sphenoid sinus with hemosinus and suprentorial pneumocephaly. the management consisted of multidisciplinary management, and the extraction was performed successfully under 3D endoscopic control.
The majority of penetrating craniofacial wounds secondary to foreign bodies, regardless of their size, are rarely associated with major neurological symptoms and their management must be adapted to their potential severity.
The majority of penetrating craniofacial wounds secondary to foreign bodies, regardless of their size, are rarely associated with major neurological symptoms and their management must be adapted to their potential severity.Transurethral resection of the prostate (TURP) compromise the mainstay surgical treatment of LUTS due to benign prostatic hyperplasia (BPH). The storage symptoms post TURP may be attributed to urinary tract infection (UTI), preoperative detrusor over-activities, and residual prostatic adenoma causing voiding symptoms.
A 56 year old male presented storage LUTS (mainly frequency and urgency) since two years. https://www.selleckchem.com/products/piceatannol.html Two years earlier, he underwent uncomplicated monopolar TURP. The patient has occasional straining and intermittent urine. No history of hematuria. No notable medical history was present. Digital rectal examination showed small prostate. Anal tone and Bulbocavernosal reflex were intact. CT showed a large vesical stone extending into the prostatic fossa measuring 51.5 mm × 67.0 mm. The patient was managed by suprapubic cystolitholapaxy.
Post TURP LUTS necessitates evaluation with a thorough history and physical, including International Prostate Symptom Score, and urine culture to rule out infection. In a rare case report, delayed occurrence of storage and obstructive voiding symptoms after TURP can be caused by dystrophic calcification of the prostatic resection cavity. The stone could have been due to a metal or plastic piece of the resectoscope embedded in the prostatic cavity, but, this postulation was deferred based on the non-attached stone to the mucosa as confirmed by cystoscope. In such case, based on the large stone burden, more cost would be a potential burden, and longer operative time, the open cystolitholapaxy is the modality of choice.
Prostatic cavity stone is a rare pathology. Incidental stone occupying the prostatic fossa post TURP is a remote possibility but it should by highlighted to raise urologist awareness for its possibility.
Prostatic cavity stone is a rare pathology. Incidental stone occupying the prostatic fossa post TURP is a remote possibility but it should by highlighted to raise urologist awareness for its possibility.The superficial temporalis artery (STA) counts as one of the most reliable blood supplies capable of supporting the vascularization of the entire scalp. Therefore, total necrosis of a scalp flap based on the superficial temporalis artery is a rare complication.
A 43-year-old woman with a history of hypertension and cerebral stroke presented to our consultation for fronto-parietal scalp alopecia. The scar was the result of spontaneous healing of a chemical burn that occurred eight months earlier. We performed the first step of scalp expansion and raised a parietal expanded goblet island flap based on the right STA. In the postoperative period, the flap developed progressive necrosis. Despite the release of tension and stab incisions, the flap failed in a week. An angio-MRI revealed a thin STA on the right compared to the left side. After debridement, the necrosis was superficial, deep galea, and some subcutaneous tissues were viable. We performed a split-thickness skin graft that achieved a total wound closure.
An extensive exploration of the vascular supply of the scalp before raising a scalp flap is not a common rule. The anatomical variation that we discovered as a thin superficial temporal artery may have explained the total failure of this flap surgery.
Surgeons should keep in mind the possible existence of a detrimental anatomical variation when planning a single pedicled scalp flap.
Surgeons should keep in mind the possible existence of a detrimental anatomical variation when planning a single pedicled scalp flap.